Levifloxacin Case Study - 1486 Words

serotonin receptor antagonists should not take Zofran. Caution in patients with a history of cardiac dysrhythmias. Zofran can cause prolonged QT and other rhythm changes (Adams Urban, 2016). There are few clinical interactions with other medications, because Zofran is metabolized in the liver by CYP450 enzymes. Any drugs that inhibit or induce this enzyme can affect availability of the Zofran in the body (Adams Urban, 2016). The oral disintegrating tablets contain phenylalanine and should not be used if you have PKU. Patients with electrolyte imbalance should be monitored closely due to increased risk of dysrhythmias. Do not drive or perform activities that require alertness (Drugs.com, 2017j). There were not any ethnopharmacological†¦show more content†¦The risk is increased in older adult patients that are transplant recipient or patients taking corticosteroids concurrently (Adams Urban, 2016). Drug interactions include, increased anticoagulant effect if taken with warf arin. Antacids with calcium, aluminum, zinc, or iron and calcium fortified beverages can decrease absorption. The patient is taking Tums, which may decrease the effect. It was recommended the Tums be discontinued due to interactions. Patients drinking caffeinated beverages may experience a buildup of caffeine in the body while on Levaquin. There were no CYP450 enzyme interactions noted as the drug is metabolized only a small amount in the liver and mostly unchanged. There are no specific ethnopharmacological or pharmacogenetic specific issues (Adams Urban, 2016). Ceftazidime-avibactam (Avycaz), is a cephalosporine combination antibiotic. It acts by inhibiting the bacteria’s cell wall synthesis, which causes the bacteria cell to lyse. The Avibactam portion of the drug, inactivates beta-lactamases and stops the breakdown of Ceftazidime (Drugs.com,2017c). The drug is widely distributed with small amounts crossing the blood brain barrier. It is not metabolized and is excreted by the kidneys. The onset of action is immediate and the half-life is greatly increased in patients with renal failure and dosage should be titrated based off the patient’s creatinine clearance (Drugs.com,2017c).